Case Reports

Arrhythmia Grand Rounds, April 2015, Volume 1, Issue 1: 3-6
DOI: 10.12945/j.agr.2015.0002-14

Acute Digitalis Delirium Associated with Intravenous Digoxin Administration

Matthew J. Lengel, PharmD1, Kun Xiang, MD, PhD2, Vincent F. Mauro, PharmD1, Blair P. Grubb, MD2, Christopher J. Cooper, MD2

1 Department of Pharmacy Practice, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, Ohio, USA

2 Division of Cardiovascular Medicine, Department of Medicine, Univesity of Toledo, Toledo, Ohio, USA


A 77-year-old woman with a reduced ejection fraction was admitted to the hospital for atrial fibrillation with a rapid ventricular rate. Intravenous digoxin was used to slow her ventricular rate. On multiple occasions in the absence of elevated serum digoxin concentrations, she demonstrated multiple episodes of acute delirium associated with the acute intravenous administration of digoxin.

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